Find Out Which Is Best for Your Needs

随着Covid-19案例的上升和新的变体，对测试的需求仍然很高。对Covid-19测试的持续需求导致了拭子和个人防护设备（PPE）的全球短缺，必须由收集棉签样本的人员佩戴。这些短缺使公共卫生官员迫使公共卫生官员向替代测试方法枢转。^1,2虽然抗原测试，也称为“快速测试”，但它们具有它们的缺点。来自血液样品的抗体检测不能用于检测活性感染，并且快速抗原试验通常与使用实时逆转录聚合酶链反应（PCR）或其他形式的核酸扩增的基于棉签的试验等同敏感。^3,4Saliva, by contrast, is gaining popularity as a swab alternative because it is easy to self-collect and less prone to supply chain disruptions. Yet one question remains: Are saliva tests as effective as nasal swabs at detecting COVID-19?

Considerations for Using Swab-based COVID-19 Tests

基于SWAB的测试被认为是Covid-19检测的金标准。最初被CDC验证为第一个Covid-19样本收集方法之一，许多接受深层鼻咽（鼻咽）拭子的人记得不舒服和侵入性经验，因为“发电机的内脏不喜欢”，⁵导致咳嗽，打喷嚏，有时甚至是血腥的鼻子。深鼻拭子对儿童特别不舒服和创伤。虽然很多在线文章^6,7offer solutions for parents wishing to get their children testing by nasal swab — from reassurance to bringing stuffed animals for emotional support — the idea of their child enduring such an irritating experience has caused many parents and patients to seek out a less invasive collection procedure or avoid being tested altogether.⁵

允许病人赛尔夫收集鼻拭子provide a sense of comfort and control. However, this approach comes with risks because patients can injure themselves or compromise the sample. Nose bleeding, retained foreign body, cerebrospinal fluid leak, and infection are all documented complications of nasal SARS-CoV-2 testing, although the former two are far more common than the latter two.⁸此外，如果自收集指令尚不清楚，患者可以在先前意外将拭子放入运输培养基中，然后进入其鼻子，其中试剂可能有害。另一方面，口服拭子和浅鼻拭子，通常可以自我管理，通常是更少的并发症。这些自收集的拭子可能有助于增加Covid-19测试的带宽。

For swab-based COVID-19 testing and other pathogen surveillance applications, safety and ease-of-use can be achieved throughSafeCollect拭子收集套件. By containing DNA/RNA Shield, a DNA/RNA stabilization reagent, under a safety seal, this swab collection device minimizes user error and allows for unsupervised collection of both oral and shallow nasal swabs. After sample collection, the swab is plunged through the safety seal into the stabilization reagent; at this point, the sample can be stored at ambient temperatures kept at room temperature for up to 30 days. Customizable user instructions can also be created by Zymo Research for better compliance in unsupervised collection settings. With direct US-based manufacturing, production capacity can be customized for each order request, ensuring access to medical equipment regardless of global supply shortages.

基于唾液的Covid-19测试的考虑因素

对于许多人来说，唾液和基于SWAB的抽样之间最显着的差异是样本收集体验。德赢体育平台游戏平台通过在管中用流口水取代侵入式拭子，基于唾液的采样允许轻松的收集减去鼻子出血和填充的支持动物。

唾液收集方法,病人护理and satisfaction come first. The non-invasive procedure can be done unsupervised, resulting in higher compliance. Most saliva collection devices involve drooling or salivating saliva into a tube up to a fill line. In addition to being pain-free, saliva-based sampling is easier and safer than a nasal swab, making the method an attractive alternative for school testing programs, targeting a critical age group for pandemic surveillance.⁹用唾液测试获得FDA Emergency Use Authorization (EUA)and从CDC清关这种替代方案真的像拭子一样准确和敏感？

Multiple systematic analyses have compiled data from around the world comparing the accuracy and efficacy of saliva-based swab-based methods for the detection and diagnosis of SARS-CoV-2. Many have found that there is no significant difference between the two collection types, suggesting that saliva specimens may be preferred over nasal swabs due to their convenience and simplicity.^9-14

一个元分析比较了拭子和基于唾液的敏感性和成本。该研究人员不仅在检测SARS-COV-2检测方法之间存在相当的敏感性，而且他们估计每个测试的唾液类样品而不是鼻咽拭子的集合将节省平均为6.36美元。¹⁵That figure quickly adds up in a pandemic where hundreds of thousands to millions of tests are administered daily.¹⁶

Choosing the Right Saliva Collection Device

When determining the best saliva collection device for your specific application, several design characteristics and features should be considered. First, you can eliminate the need for cold storage and shipping by choosing a collection device that uses a nucleic acid stabilization reagent. Such devices not only minimize shipping and transportation costs but remove the chance of sample integrity loss from compromised storage conditions. Additionally, having a collection device with a stabilization solution already housed within ensures the highest quality of saliva is obtained and preserved from its immediate collection time until it’s tested. Finally, with at-home and unsupervised sample collection becoming increasingly common, saliva collection devices must be user-friendly and prioritize not only safety but consistent sampling as well.

The foolproof design of Zymo Research’sSafecollect Saliva Collection套件has several features that make for safe and streamlined saliva sample collection:

• 易于使用的集合漏斗，简化了唾液采样过程
• DNA / RNA护罩，同时灭活病原体的试剂并在环境温度下稳定唾液中的核酸长达30天
• 一种安全密封，将唾液样品与DNA / RNA屏蔽试剂分开，仅当盖帽在收紧时刺穿密封时

可通过我们的团队设计和制造完全可定制的用户说明，以专门符合您的应用程序需求，保证对样本收集过程中的绝对透明度和一致性。

Swabs or saliva, Zymo Research’s products utilize a US-based manufacturer who directly controls their own supply chain, protecting its production capacity against shortages and guaranteeing fulfillment across all orders.

February 03, 2022